Temporal change of ventricular repolarization indices and index of cardioelectrophysiological balance (iCEB) during COVID-19 treatment including hydroxychloroquine at a tertiary referral hospital

Aim: Hydroxychloroquine (HCQ) is widely administered to patients with confirmed or suspected COVID-19. It may increase the risk of cardiac arrhythmias associated QT and QTc prolongation. This study aimed assess change in iCEB, a new marker drug-induced arrhythmia, other repolarization parameters COVID-19 treated short-course HCQ.
 Material Method: was retrospective cross-sectional including 40 hospitalized according CT findings HCQ. Serial assessments intervals calculation index cardio-electrophysiological balance (iCEB) were performed using standard 12 lead electrocardiogram before hydroxychloroquine treatment, on second day HCQ after last dose. 
 Results: QT, QTcB, QTcF, iCEBcB significantly increased treatment compared baseline (p=0.009, p=0.001, p=0.002, p=0.047, p=0.05, respectively). Similarly, iCEBcF higher fifth (p=0.011, p=0.005, p=0.013, p=0.028, p=0.024 However, there no differences between days for any studied parameters.
 Conclusions: QTc, iCEB day, remained treatment. The attributed amount loading dose duration Our suggests that, along ECG markers, can be used